The Truth About Hydroxychloroquine

If you are looking for evidence to suggest that this drug helps with COVID-19 treatment, you’d be hard pressed to find it. You can draw your own conclusions from the following…

From the BBC…

The death rates of the treated groups were: hydroxychloroquine 18%; chloroquine 16.4%; control group 9%. Those treated with hydroxychloroquine or chloroquine in combination with antibiotics had an even higher death rate.

via BBC

From MySanAntonio…

The dangerous side effects of the drugs are much better known. Most seriously, the drugs can trigger arrhythmia, which can lead to a fatal heart attack in patients with cardiovascular disease or who are taking certain drugs, including anti-depression medications. Doctors recommend screening with an electrocardiogram to prevent the drug from being given to the 1% of patients at the greatest risk of a cardiac event. The drugs also can cause vision loss called retinopathy with long-term use, and chloroquine has been associated with psychosis.

via MSA

From The Journal of the American Medical Association…

Findings  In this phase IIb randomized clinical trial of 81 patients with COVID-19, an unplanned interim analysis recommended by an independent data safety and monitoring board found that a higher dosage of chloroquine diphosphate for 10 days was associated with more toxic effects and lethality, particularly affecting QTc interval prolongation. The limited sample size did not allow the study to show any benefit overall regarding treatment efficacy.

Meaning  The preliminary findings from the CloroCovid-19 trial suggest that higher dosage of chloroquine should not be recommended for the treatment of severe COVID-19, especially among patients also receiving azithromycin and oseltamivir, because of safety concerns regarding QTc interval prolongation and increased lethality.

via JAMA

And last but not least, from the New England Journal of Medicine…

Of 1446 consecutive patients, 70 patients were intubated, died, or discharged within 24 hours after presentation and were excluded from the analysis. Of the remaining 1376 patients, during a median follow-up of 22.5 days, 811 (58.9%) received hydroxychloroquine (600 mg twice on day 1, then 400 mg daily for a median of 5 days); 45.8% of the patients were treated within 24 hours after presentation to the emergency department, and 85.9% within 48 hours. Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine (median ratio of partial pressure of arterial oxygen to the fraction of inspired oxygen, 223 vs. 360). Overall, 346 patients (25.1%) had a primary end-point event (180 patients were intubated, of whom 66 subsequently died, and 166 died without intubation). In the main analysis, there was no significant association between hydroxychloroquine use and intubation or death (hazard ratio, 1.04, 95% confidence interval, 0.82 to 1.32). Results were similar in multiple sensitivity analyses.

via NEJM

Exhausting Audiobook Series

via TMBD Productions

I have a page link in the upper right hand corner called “Exhausting Book Series.” These are book series that I’ve listened to up to the point where I just couldn’t go on anymore. I believe the “Ashes” trilogy was the only series where I had to stop almost immediately after starting because the reader was over emotional. I’ve updated the section with other options from Audible on why others feel the same way I do about them. I was pleasantly surprised to see that someone felt exactly the same way about the Ashes Trilogy. You may agree or disagree. Feel free to leave a comment either way.

iPad Appreciation

I usually manage this website using my laptop or my iMac. I needed to change the current book I am reading and thought it would be a good time to test the ability of the iPad Pro I use. It is not the latest one but it still packs a good punch when it comes to getting work done.

I am not using the traditional style keyboard to write this post. Just the touch screen keyboard. To properly post a new book, I need to grab some artwork for the book, load that via FTP to my website, and then add the book details to the plugin I use. This was all easily accomplished by just using my iPad.

Sometimes I forget just what a wondrous device this truly can be. Even the spell checking works really well and substitutes words effortlessly. My iPad Pro is a machine I use mostly for playing Idle Champions of the Forgotten Realms but it is capable of so much more. You could draw pictures. You could, maybe. I cannot. I have the pencil but not the required skills to really draw anything. That is ok. I think I do much better at writing.

COVID-19 Thoughts

More here

This is unlike any outbreak I’ve experienced in my lifetime. Movie studios, entire towns, and businesses are shutting down. Supplies in local stores are running low as people freak out. Unless you are a “prepper”, of course and you’ve always seen something like this coming.

The business I am in is shipping and order fulfillment. People that can work from home will still be able to be paid and will continue to order things online. Unfortunately, there will be other people who are not so lucky. Their jobs could be at risk because they are unable to work from home.

This can only get worse as time goes on.